The New York Giants and Detroit Lions will match up in Week 12 of the 2025 NFL season with both franchises trending in opposite directions. The Giants are operating under an interim head coach and will be without rookie sensation Jaxson Dart (concussion) again for this contest, while the Lions try to bounce back from a loss to the Eagles on Sunday Night Football in Week 11 to prove they are still contenders. The Giants are 2-9 entering this game, while the Lions are 6-4. According to the latest Giants vs. Lions odds, Detroit is favored by 13.5 points, while the over/under for total points scored is 50.5.

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