Nov 16, 2025; Denver, Colorado, USA; Kansas City Chiefs quarterback Patrick Mahomes (15) before the game against the Denver Broncos at Empower Field at Mile High. Mandatory Credit: Ron Chenoy-Imagn Images

Patrick Mahomes and the Kansas City Chiefs will face off against Dak Prescott and the Dallas Cowboys in a must-see Thanksgiving Day clash on Thursday (4:30 p.m. ET, CBS).

Mahomes and the Chiefs snapped a losing streak with an overtime victory over the Indianapolis Colts on Sunday, while the Cowboys are coming off an upset victory over the defending champion Philadelphia Eagles.

Looking to make a bet on Thursday's game? We've got you covered with the latest odds from DraftKings Sportsbook and our prediction for Chiefs vs. Cowboys.

Missouri sports betting launches December 1st

Chiefs fans in Missouri will soon be able to bet on their team from home, as online sports betting will go live on December 1st. Users that pre-register can receive up to $300 in bonus bets on launch day.

Sign up for DraftKings in Missouri

Chiefs at Cowboys odds

Provided by DraftKings Sportsbook

  • Moneyline (ML): Chiefs -180 (bet $180 to win $100) | Cowboys +150 (bet $100 to win $150)
  • Against the spread: Chiefs -3.5 (-105) | Cowboys +3.5 (-115)
  • Over/Under (O/U): 52.5 (O: -110 | U: -110)

Chiefs at Cowboys key injuries

Chiefs

  • G Trey Smith (ankle) out
  • TE Noah Gray (concussion) out
  • CB Chris Roland-Wallace (back) out

Cowboys

  • OT Tyler Guyton (ankle) out
  • CB Caelen Carson (hamstring) is questionable

Chiefs at Cowboys picks and predictions

Prediction

Chiefs 27, Cowboys 20

Against the spread

Play the Chiefs -3.5 (-105) on the road - but think about adjusting the spread to -3. Dak Prescott gives Dallas a puncher's chance against any team, but the Cowboys have been far too inconsistent this season, and their Week 12 upset over Philadelphia is the Cowboys' only win against a team with a winning record.

Despite their struggles this season, the Chiefs still have an excellent defense (4th in total points allowed) and need a win to solidify their Wild Card position - especially with tougher games against the Texans and Chargers coming up.

Against teams outside of playoff position this season (Giants, Raiders, Commanders), the Chiefs have won by an average of 21.6 points - though the Cowboys are a level above any of those teams.

Over/Under

Under 52.5 (-110) is worth a look on Thanksgiving Day. The Chiefs have gone under that total in five of their last six games, and the Cowboys have gone under 52.5 in three straight. The acquisition of Quinnen Williams has bolstered the Cowboys' defense significantly in recent weeks, so this shouldn't be a shootout game.

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This article originally appeared on For The Win: Chiefs vs. Cowboys prediction, latest odds from DraftKings Sportsbook

Reporting by Nick Schwartz, For The Win / For The Win

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