Iowa State football concludes its 2025 regular season on Saturday, Nov. 29, with a Big 12 Conference road game against Oklahoma State.

The Cyclones (7-4, 4-4 Big 12) are coming off a 38-14 victory over Kansas on senior day at Jack Trice Stadium in Ames.

The Cowboys (1-10, 0-8) are losers of 10 straight games, most recently 17-14 at UCF.

Here are some predictions and the betting lines for the game: Stream Iowa State vs. Oklahoma State for free on FUBO Expert MLB daily picks: Unique MLB betting insights only at USA TODAY

Iowa State vs. Oklahoma State odds, moneyline, over/under

Odds courtesy of BetMGM as of Friday evening.

Spread : Iowa State -13.5

Moneyline: Iowa State -555, Oklahoma State +405

Over/under : 46.5

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