The 2025 Palmetto Bowl unfolds Saturday when the South Carolina Gamecocks host the Clemson Tigers. It's been a disappointing season for both sides with South Carolina entering at 4-7 and Clemson at 6-5. The Tigers, however, have some momentum as they enter this matchup on a three-game winning streak. Clemson leads this series 73-44-4, though South Carolina has won two of the last three. South Carolina is expected to have receiver Nyck Harbor and defensive end Dylan Stewart available after both missed last week's game against Coastal Carolina.

Kickoff is at noon ET from Williams-Brice Stadium. The Gamecocks are 2.5-point favorites in the latest South Carolina vs. Clemson odds, while the over/under is 46.5. Before making any Clemson vs. South Carolina picks, check out the college football

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