The Week 13 NFL schedule has already seen four upsets over the course of Thanksgiving and Black Friday. There's plenty more to come over the weekend, however. The other standalone games to make Week 13 NFL picks on are both Super Bowl rematches. Broncos vs. Commanders saw Washington prevail in The Big Game back in 1988, and the Week 13 NFL odds have Denver as 5.5-point road favorites on Sunday night, with Jayden Daniels (elbow) ruled out. Then on Monday, Giants vs. Patriots (-7.5) is a matchup we've seen twice in the Super Bowl, with New York winning each time.

Sunday afternoon's slate features a couple of matchups where time and travel could be factors with your Week 13 NFL picks. Cardinals vs. Buccaneers (-4.5) and Rams vs. Panthers (+10.5) both see the NFC West teams flying to the East

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