Highly notable rookie quarterback Shedeur Sanders will make his second start for the Cleveland Browns when they host the San Francisco 49ers in Week 13 of the NFL season. Sanders got the ball for Cleveland (3-8) in Week 12 and defeated the Las Vegas Raiders on the road, and defensive superstar Myles Garrett continued his march towards challenging the single-season sacks record. San Francisco (8-4) beat the Carolina Panthers on Monday Night Football.

Kickoff from Huntington Bank Field is set for 1 p.m. ET on CBS and Paramount+ . The 49ers are 4.5-point favorites, according to the latest Browns vs. 49ers odds . The over/under for total points scored is 36.5. Before making any Browns vs. 49ers picks, make sure you check out the NFL picks from the SportsLine Projection Model. Be

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