The Arizona Cardinals and Tampa Bay Buccaneers are both dealing with quarterback injuries heading into their Week 13 matchup during the 2025 NFL season. It's confirmed Kyler Murray won't suit up because he's still on injured reserve, but Bucs star Baker Mayfield is trending towards starting despite a sprained AC joint in his non-throwing shoulder. The Cardinals are in the conversation for the No. 1 pick, while the Bucs hope to get back to the postseason for a sixth year in a row.

Kickoff from Raymond James Stadium in Tampa is set for 1 p.m. ET and the Buccaneers are 3-point favorites in the latest Cardinals vs. Buccaneers consensus odds . The total comes in at 44.

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