A spot in the College Football Playoff bracket is on the line for the No. 17 Virginia Cavaliers when they meet the Duke Blue Devils in the 2025 ACC Championship Game on Saturday. The Cavaliers finished the regular season 10-2 overall with a 7-1 ACC record. They now have an inside track for an automatic CFP bid as one of the five highest-ranked conference champions if they can get by the Blue Devils.

Kickoff from Bank of America Stadium in Charlotte is at 8 p.m. ET. The Cavaliers are 3.5-point favorites in the latest Virginia vs. Duke odds, while the over/under is 58.5. Before making any Duke vs. Virginia picks, check out the college football predictions from the SportsLine Projection Model .

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