LA Rams at Arizona Cardinals odds, picks and predictions

Los Angeles Rams quarterback Matthew Stafford (9) looks to pass at Bank of America Stadium in Charlotte, North Carolina.

The LA Rams (9-3) visit the Arizona Cardinals (3-9) Sunday in Week 14. Kickoff from State Farm Stadium in Glendale, Arizona, is set for 4:25 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the Rams vs. Cardinals odds and make our expert NFL picks and predictions for the best bets.

The Rams lead the NFC West and are the No. 2 seed in the NFC playoff picture. They have won 6 of their last 7 games but are coming off a 31-28 road loss to the Carolina Panthers last Sunday. They failed to cover as 10.5-point favorites and the Over (45) cashed. Rams QB Matthew Stafford threw 2 interceptions, ending a streak of 28 straight touchdown passes without a pick, and the Rams couldn't slow Carolina's run game, which rushed for 164 yards in the game.

The Cardinals have lost 4 straight games and 9 of their last 10. They are 1-6 since QB Jacoby Brissett replaced Kyler Murray in the lineup following a foot injury that will sideline him for the rest of the season. They lost last week, 20-17, to the Tampa Bay Buccaneers, covering as 4-point underdogs with the Under (45.5) cashing.

In 94 all-time meetings, including 2 in the postseason, the Rams lead 51-41-2. The Rams won the last matchup in December 2024, a 13-9 home win, with the Cardinals covering as 6.5-point underdogs and the Under (48) cashing.

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Rams at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 3:11 p.m. ET.

Moneyline (ML): Rams -500 (bet $500 to win $100) | Cardinals +375 (bet $100 to win $375)
Against the spread (ATS): Rams -9.5 (-110) | Cardinals +9.5 (-110)
Over/Under (O/U): 47.5 (O: -110 | U: -110)

Rams at Cardinals key injuries

Rams

WR Tutu Atwell (hamstring) questionable
DT Poona Ford (calf) questionable
RT Rob Havenstein (ankle) injured reserve
CB Darious Williams (tibia) doubtful

Cardinals

OL Kelvin Beachum (groin) questionable
RB Trey Benson (knee) out
DL L.J. Collier (knee) out
RB Emari Demercado (ankle) out
WR Greg Dortch (chest) out
WR Marvin Harrison Jr. (heel) out
CB Max Melton (heel) out
QB Kyler Murray (foot) out for season
DL Walter Nolen (knee) out

Rams at Cardinals picks and predictions

Prediction

Rams 37, Cardinals 20

Moneyline

The Cardinals have not won at home since Week 2. The Rams, prior to their loss to the Panthers, had held opponents to 19 or fewer points in 5 of 6 games.

The Cardinals are 0-4 in division games this season and have beaten the Rams only 3 times while Sean McVay has been their coach.

They are missing several weapons on offense, and Brissett is not a winning starter, going 1-6 this season, 2-10 over his last 2 seasons and 20-40 in 60 career starts.

The Rams will take care of business to keep pace in the NFC, but the spread offers much better value than the moneyline in a Rams win.

PASS.

Against the spread

While the Cardinals have been in nine 1-score games this season, they have lost their last 7. And with Brissett starting, their 2 previous games against NFC West opponents were 3-score losses.

Six of the Rams’ 9 wins have been by double digits.

BET RAMS -9.5 (-110).

Over/Under

The Over has cashed in 6 of the Cardinals' last 8 games. They have allowed more than 40 points in their last 2 NFC West games. The Rams have scored more than 30 in 4 of their last 6 games.

BET OVER 47.5 (-110).

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This article originally appeared on Sportsbook Wire: LA Rams at Arizona Cardinals odds, picks and predictions

Reporting by Jess Root, Sportsbook Wire / Sportsbook Wire

USA TODAY Network via Reuters Connect