The San Francisco 49ers haven’t been on the right side of injury luck in some time now under Kyle Shanahan. That variance feels like it’s been amplified in 2025 for all of the wrong reasons. Shanahan is no stranger to injuries at quarterback. His backup, Mac Jones, helped salvage the Niners’ season.

In Week 16, the 49ers will be the beneficiary against the Indianapolis Colts. Daniel Jones suffered a season-ending Achilles tear in his right leg in the first quarter of Sunday’s loss to the Jacksonville Jaguars. Jones was already playing through what was reported to be a hairline fracture in his left fibula.

Jones beat out former first-round pick Anthony Richardson, who is currently on the injured reserve. Richardson suffered a broken orbital during warmups in Week 6. While Richardson is el

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