Asia-Pacific markets were mostly lower on Tuesday after losses on Wall Street, with investors holding back ahead of the U.S. Federal Reserve's decision on Dec. 10 stateside.

The central bank is widely expected to cut rates by another 25 basis points at its final meeting of the year, bringing the Federal Funds rate to 3.5%-3.75%. However, experts said the Fed will then take a more data-dependent stance.

"I would not be surprised for Jerome Powell to be like, 'We've cut, and now we're in a place where we really need to watch the data,' and he'll stop just short of being hawkish, because we have seen the softness in the labor market," said Stephen Kolano, chief investment officer at Integrated Partners.

The Nikkei 225 was up 0.14% in a volatile trading session, closing at 50,655

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