The Week 15 NFL schedule features 16 more games, including several with potential playoff ramifications. One such game is an AFC East battle between the Buffalo Bills (9-4) and New England Patriots (11-2). Buffalo is favored by 1.5 points as Josh Allen and the Bills take on Drake Maye and the Patriots. Buffalo is on a two-game winning streak, while New England has won 10 straight.

Another key matchup is between two NFC contenders as the Detroit Lions (8-5) clash with the Los Angeles Rams (10-3). The Lions are battling for a playoff spot, while the Rams are seeking to retain the No. 1 seed in the conference. Detroit has won the last two meetings, including a 26-20 overtime win in September 2024. The Rams enter as 5.5-point home favorites. Sunday's largest spreads include Raiders vs. Eagles

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