An immigrant grandmother was left suffering severe memory loss and is forced to breathe through a hole in her neck following a savage beatdown at a Queens nightclub , her son told the Daily News.

Josephine Estrella, 54, was at Suit 36 located on 36th St. near 37th Ave. in Astoria when a man and woman struck her multiple times around 4:14 a.m. on Oct. 19, cops said.

Luis Jimenez, 33, said his family was celebrating his wife’s 33rd birthday at the Astoria nightclub when his brother-in-law was somehow drawn into a dispute between the wait staff and another party of about 10 people.

The victim’s family had rushed to their relative’s aid when Estrella was attacked and fell to the floor, striking her head, her son said.

“They turned on my brother-in-law, but he doesn’t speak English,” said

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