With four games remaining in the 2025 NFL regular season, the San Francisco 49ers may need to win out to secure a playoff berth. This 49ers vs Tennessee Titans preview breaks down what the 49ers must do in Week 15 as they return from their bye to face the struggling 2–11 Titans. Here are three keys for San Francisco to avoid an upset against a team that has already turned the page to 2026.

49ers vs Titans Preview: Week 15 Keys to Victory

Pressure Tennessee’s Quarterback

San Francisco’s pass rush has struggled all year. Season-ending ACL injuries to All-Pro Nick Bosa and rookie first-rounder Mykel Williams removed the team’s top two edge threats. Without Bosa, the 49ers have totaled just 16 sacks, the fewest in the NFL.

This week provides an opportunity for Clelin Ferrell, Bryce Huff, a

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