Louisville Cardinals guard Ryan Conwell (3) reacts after his team scores at Gainbridge Fieldhouse in Indianapolis.

The Memphis Tigers (4-4) visit the No. 11 Louisville Cardinals (8-1) for a Saturday-afternoon non-conference affair. The contest at the KFC Yum! Center in Louisville, Kentucky, will tip off at 3:30 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's NCAA basketball odds around the Memphis vs. Louisville odds and make our expert college basketball picks and predictions for the best bets.

Memphis last played a week ago when the Tigers downed -3.5 Baylor 78-71 (Under 158). UM, which lost 4 straight from Nov. 11-21, has won each of its last 3 games. During the win streak, the Tigers have held opposing shooters to a 35% mark from the field.

Louisville, which has not played Memphis since 2017, also played its most recent game last Saturday. The Cardinals topped then-No. 19 Indiana 87-78 (Over 162.5), bouncing back from a Dec. 3 loss to No. 17 Arkansas.

UM and UL have met 86 times since 1949. Over that stretch, the Cardinals lead the series 50-36.

– Rankings: USA TODAY Sports Coaches Poll

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Memphis at Louisville odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:28 a.m. ET.

  • Moneyline (ML): Memphis +850 (bet $100 to win $850) | Louisville -1600 (bet $1,600 to win $100)
  • Against the spread (ATS): Memphis +15.5 (-110) | Louisville -15.5 (-110)
  • Over/Under (O/U): 160.5 (O: -110 | U: -110)

Memphis at Louisville picks and predictions

Prediction

Louisville 86, Memphis 69

Moneyline

No interest; PASS.

Against the spread

Memphis has played a tough slate so far, but the defense they will see at Louisville is a top-notch disruptive one. UL excels in consistently contesting shots at all 3 levels and is adept in forcing suboptimum attempts inside the arc. The Tigers have been loose with the basketball, and the Cardinals should be able to maintain a big edge in quality possessions.

Louisville's rim-and-3 rate is through the roof, and that style of ball is something the Tigers have not seen much. Big advantages in turnovers, free-throw frequency and perimeter shooting play into a favorable view of the Cardinals in this spot.

TAKE LOUISVILLE -15.5 (-110).

Over/Under

The Under is 4-1 across UM's last 5 games and has cashed in UL's last 2 contests at home. The Cardinals were a home favorite 16 times last season, and the Under went 11-5.

Louisville struggled on defense 2 games back in their only loss of the season (Dec. 3 vs. No. 17 Arkansas). But the veteran Cardinals bounced back with a nice defensive effort against Quad IA Indiana in their last.

Look for some pace to this matchup, but UL should be able to counter a Memphis offensive rebounding strength. And the Tigers likely lack the 3-point shooting to muster a late charge.

The UNDER 160.5 (-110) is the value side here.

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This article originally appeared on Sportsbook Wire: Memphis Tigers at Louisville Cardinals odds, picks and predictions

Reporting by Skip Snow, Sportsbook Wire / Sportsbook Wire

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