Where there’s smoke, there’s ire.

Upper West Side residents are burning up after a hoodlum spray-painted the word “SMOKE” on dozens of businesses spanning more than 20 city blocks of Columbus Avenue on the Upper West Side.

“It was on bus shelters, buildings, garbage cans, everything. It was horrible. I mean, I never, to be honest with you, I’ve never seen a tag like this, and I’ve seen a lot of graffiti,” City Councilwoman Gale Brewer fumed.

The “SMOKE” tag, first spotted Monday, spread like a virus from 72nd to 96th streets, with some 30 buildings defaced.

“It’s not good for business, it’s not their building, it makes it look trashy,” said Layla Ross 21, a sales associate at Pet Market on 93rd Street, whose workplace escaped the vandal’s spray can.

Ella Social restaurant, on 72nd a

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