SANTA CLARA — Brandon Aiyuk has officially left the 49ers’ building — and roster, likely forever.

Aiyuk’s stalled comeback from last season’s knee injury turned into such a vanishing act that the 49ers reclassified his status Saturday as “reserve/left squad.”

Aiyuk did not previously count against the 53-man roster with his reserve/physically-unable-to-perform list, and now the 49ers are essentially announcing he’s not returning this season nor in the foreseeable future.

Although the 49ers voided $27 million in 2026 guarantees back in late July for reportedly violating terms of his knee rehabilitation, Aiyuk maintained a very visible presence during training camp and the first month of the season as he shadowed wide receivers’ warmups.

He vanished from the media’s sight once October ar

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