Two people were killed when a high-speed, wrong-way driver slammed into oncoming traffic in Santa Ana on Monday afternoon, causing a five-car crash that left several others hospitalized.

It happened at around 6:40 p.m. in the 2200 block of S. Main Street, according to the Santa Ana Police Department.

The aftermath of a high-speed, wrong-way crash in Santa Ana on Aug. 4, 2025. KCAL News

Investigators believe that one of the drivers, behind the wheel of a gray sedan, was driving on the wrong side of the road at an extremely high rate of speed when they collided head-on with another vehicle, which was traveling southbound on Main.

One of the two cars spun out and then crashed into three other vehicles.

Both of the drivers, one male and one female, in the two cars involved in the initia

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