Key Takeaways

An oral monotherapy regimen could simplify treatment for plague in rural areas where it is most common.

In a randomized trial, treatment failure occurred in 9% of those who received oral ciprofloxacin versus 8.1% of those who received injectable aminoglycoside and oral ciprofloxacin.

This study's 4% case fatality rate overall was far below the 23% rate seen in Madagascar at locations that weren't in the trial's recruitment areas.

Oral ciprofloxacin alone was as effective as a regimen combined with an injectable antibiotic for bubonic plague, a randomized trial showed.

Among 222 patients with confirmed or probable infection in Madagascar, treatment failure occurred in 9% of those who received oral ciprofloxacin for 10 days versus 8.1% of those who received injectable amin

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