TOPLINE:
Individuals with overweight or obesity have a higher risk for atrial fibrillation (AF) than those with normal weight. Nearly one fourth of the increased risk with obesity is mediated by comorbid conditions, whereas the remaining risk is directly mediated by obesity.
METHODOLOGY:
Obesity is associated with an increased risk for AF, yet it remains unclear whether this risk stems directly from excess adiposity or is mediated by comorbid conditions.
Researchers conducted a retrospective cohort study of patients aged ≥ 40 years with a documented BMI across German general practices between 2005 and 2023.
Participants were categorized as underweight (BMI < 18.5), normal weight (18.5-24.9), overweight (25.0-29.9), or obesity (≥ 30).
The primary outcome was incident AF within 10