TOPLINE:

In a 14-year study of 6217 patients with chronic lymphocytic leukemia (CLL), regular immunoglobulin replacement therapy (IgRT) was associated with higher infection rates during treatment periods than during nontreatment periods. Monthly infection-related hospitalizations doubled, while IgRT use quadrupled over the study period.

METHODOLOGY:

Researchers conducted a retrospective longitudinal analysis of 6217 patients diagnosed with CLL between 2008 and 2022 in Victoria, Australia, using linked hospital and death data.

Analysis included Kaplan-Meier survival analyses to estimate survival, infection incidence, and IgRT use, while Cox survival analyses explored associations between infections and IgRT in regular prophylactic users.

Investigators tracked 753 patients (12.1%) who r

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