AFC meets NFC in an in-state 2025 NFL preseason battle as the Buffalo Bills host the New York Giants on Saturday. The Bills topped the AFC East last season with a 13-4 record, and are looking to have another strong season before making a deeper playoff run. Meanwhile, the Giants finished 3-14 in the NFC East and have plenty of questions heading into their 2025 campaign as Russell Wilson heads core of new quarterbacks battling for playing time.

Kickoff from Highmark Stadium in Buffalo is set for 1 p.m. ET. Buffalo is a 2.5-point favorite in the latest Bills vs. Giants odds, while the over/under for total points scored is 36.5. Before locking in any Giants vs. Bills picks or predictions, you need to see what proven SportsLine's R.J. White has to say. New users at BetMGM can get the

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