The Denver Broncos will face the San Francisco 49ers in their 2025 preseason opener at Levi's Stadium on Saturday, August 9, 2025. The game is set to begin at 8:30 PM ET and will be broadcast on ABC in Salt Lake City and KPIX 5-CBS in San Francisco. Fans can also stream the game on Fubo.

As the NFL preseason kicks off, both teams are preparing for their regular season games. However, many star players are expected to sit out this matchup. Notable absences may include Patrick Surtain, George Kittle, and Christian McCaffrey.

Despite the likely absence of key players, there are intriguing storylines to follow. Broncos head coach Sean Payton hinted that quarterback Bo Nix might see some action. Nix, who impressed as a rookie, is looking to build on his performance in his second season. Getting some game reps, even for a short time, could be beneficial for his development against an opposing defense.

This matchup promises to be an exciting start to the preseason, and fans are encouraged to tune in to catch all the action. Regional restrictions may apply.