New York Yankees rookie starting pitcher Cam Schlittler (31) delivers a pitch against the Houston Astros at Yankee Stadium in Bronx, New York.

The Minnesota Twins (56-63) and New York Yankees (64-56) wrap up their 3-game series Wednesday. First pitch from Yankee Stadium in Bronx, New York, is set for 7:05 p.m ET (Prime Video). Let's analyze BetMGM Sportsbook's MLB odds around the Twins vs. Yankees odds and make our expert MLB picks and predictions for the best bets.

Season series: Yankees lead 2-0

The Yankees followed up their 6-2 series-opening win with a dominant 9-1 victory over the Twins on Tuesday night, cashing as -204 home favorites as the Over (9) hit. SP Carlos Rodón earned his first win of August with a strong outing (7 IP, 1 ER, 1 H, 2 BB, 5 K). RF Giancarlo Stanton went 4-for-5 with a home run, a double, and 3 RBIs. DH Aaron Judge crushed his 38th homer and SS Anthony Volpe added a 3-run blast.

The Twins have been outscored 15-3 in this series. SP Travis Adams struggled (2 1/3 IP, 4 ER, 4 H, 4 BB, 2 K, 2 HR), while the offense managed just 1 hit and 1 run. That lone run came on a fielder’s choice groundout by 3B Royce Lewis.

Twins at Yankees projected starters

RHP Joe Ryan vs. RHP Cam Schlittler

Ryan (11-5, 2.79 ERA) is making his 24th appearance and 23rd start. He has a 0.92 WHIP, 1.7 BB/9 and 9.9 K/9 through 132 1/3 innings.

  • Last start: Win, 5 IP, 1 ER, 4 H, 0 BB, 5 K in 9-4 victory against the Kansas City Royals Friday
  • 2025 road stats: 5-2, 2.55 ERA (67 IP, 19 ER), 0.88 WHIP, 8.9 K/9 in 11 starts
  • Career vs. Yankees: 2-2, 3.86 ERA (23 1/3 IP, 10 ER), 1.03 WHIP, 9.6 K/9 in 4 starts; last in 2024

Schlittler (1-2, 4.38 ERA) is making his sixth career start. The 24-year-old rookie has a 1.66 WHIP, 4.4 BB/9 and 8.8 K/9 through 24 2/3 innings.

  • Last start: No-decision, 5 IP, 2 ER, 7 H, 1 BB, 3 K in 5-3 loss against the Houston Astros Friday
  • 2025 home stats: 1-1, 4.91 ERA (14 2/3 IP, 8 ER), 1.71 WHIP, 9.2 K/9 in 3 starts
  • Has never faced the Twins

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Twins at Yankees odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:37 a.m. ET.

  • Moneyline (ML): Twins +125 (bet $100 to win $125) | Yankees -150 (bet $150 to win $100)
  • Run line (RL)/Against the spread (ATS): Twins +1.5 (-185) | Yankees -1.5 (+150)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

Twins at Yankees picks and predictions

Prediction

Yankees 7, Twins 3

Moneyline

PASS.

The Yankees (-150) will continue their dominance in this series which is why I'll take my wager to the plus-money run line.

Run line/Against the spread

BET YANKEES -1.5 (+150).

The Yankees entered their series with the Twins in a slump, but they’ve quickly turned things around. Through the first 2 games, New York has scored 5 times as many runs as Minnesota and improved to 37-24 at home. They remain one of only 2 MLB teams to hit over 100 HRs at home (104; LA Dodgers have 110), with Judge blasting his 17th at Yankee Stadium Tuesday.

Minnesota’s road struggles continue, as they are just 24-38 away from home while hitting a meager .229 in those games, ranking 25th in MLB. Even with Ryan, who’s been solid this season, starting Wednesday, slowing down the Yankees’ surging offense will be a challenge. New York will counter with rookie Schlittler, who has yet to allow more than 3 earned runs in any of his 5 starts.

The Yankees, who have only a 1-game cushion over the Cleveland Guardians for the final Wild Card spot, should close their 6-game homestand on a winning note.

Over/Under

BET OVER 8.5 (-115).

The Over has been a frequent result when the Yankees and Twins meet, cashing in 3 of the last 4 matchups. Minnesota has hit the Over in 7 of its last 10 games and in 6 of their last 8 road contests. Additionally, the Over has cashed in 2 of Ryan’s last 3 starts. The trends point toward backing the Over again on Wednesday.

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This article originally appeared on Sportsbook Wire: Minnesota Twins at New York Yankees odds, picks and predictions

Reporting by Drew Phelps, Sportsbook Wire / Sportsbook Wire

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