The 2025 college football season has finally arrived, with the Week 0 college football schedule taking place on Saturday, Aug. 23. The slate is headlined by a Big 12 matchup between Kansas State and Iowas State in Ireland, which is hosting a college football game for the 10th time. Kansas State is the pre-season favorite in the Big 12 and the Wildcats are 3.5-point favorites in the latest Week 0 college football odds.

Other Week 0 college football spreads involving Power Four teams are Kansas (-14) against Fresno State and Hawaii (-2.5) against Stanford in the nightcap. Western Kentucky (-9.5) vs. Sam Houston is the other matchup on the slate in a battle of Group of Five teams. Before locking in any college football picks for Week 0 of the 2025 season, be sure to see the college football

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