TOPLINE:

Clozapine use was associated with a 25% higher risk for infections in patients with schizophrenia than the use of olanzapine, with a 45% higher risk in those aged 55 years or older, a large cohort study showed.

METHODOLOGY:

The population-based cohort study included electronic health record data from the Hong Kong Hospital Authority for more than 11,051 adults with schizophrenia.

Participants had used clozapine (n = 1450; mean age, 41 years; 52% women) or olanzapine (n = 9601; mean age, 45 years; 55% women) continuously for 90 or more days and had previously used at least two other antipsychotic medications, representing a cohort with treatment resistance.

The primary outcome was occurrence of any infectious disease, with subtypes analyzed as secondary outcomes.

Medication w

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