TOPLINE:

Compared with a very low-calorie ketogenic diet (VLCKD) alone, combining a VLCKD with liraglutide led to greater weight loss and metabolic improvements over 4 months in adults with obesity.

METHODOLOGY:

VLCKD induces weight loss by enhancing satiety through sustained ghrelin suppression and minimizes muscle loss, but because long-term dietary adherence is challenging, researchers investigated whether combining a protein-rich VLCKD with the GLP-1 receptor agonist liraglutide could synergistically suppress appetite via both ghrelin-dependent and -independent pathways.

They conducted an observational, real-world study to compare the weight-loss effects, metabolic effects, and safety of a VLCKD alone with the same diet combined with liraglutide in adults with obesity (BMI > 30) ov

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