TOPLINE:

A history of pregnancy complications was associated with an increased risk for ischemic stroke, particularly atherothrombotic stroke, a new cohort study showed. The risk was especially high among women with complications such as hypertensive disorders of pregnancy, small-for-gestational-age births, and preterm deliveries.

METHODOLOGY:

The case-cohort study included more than 300 women (age, 18-49 years; 736 total previous pregnancies) with first-ever ischemic stroke from the prospective ODYSSEY study.

These women were frequency-matched for age at the most recent pregnancy with more than 700 women (1431 previous pregnancies) without ischemic stroke from the PRIDE study.

Pregnancy complications included miscarriage (at < 20 weeks of gestation), hypertensive disorders of pregnan

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