TOPLINE:

Rheumatoid arthritis (RA) was causally linked to the development of idiopathic pulmonary fibrosis , with shared plasma factors CC motif chemokine ligand 2 (CCL2) and CXC motif chemokine ligand 2 (CXCL2) identified as potential diagnostic biomarkers.

METHODOLOGY:

Idiopathic pulmonary fibrosis shares inflammatory and fibrotic features with RA, but the causal relationship is unknown. Researchers conducted a bidirectional Mendelian randomization analysis using genome-wide association study data from European cohorts to explore causality between the two conditions.

They analyzed the data of 14,361 patients with RA and 42,923 control individuals as well as data from 1028 patients with idiopathic pulmonary fibrosis and 196,986 control individuals.

Significant single nucleotide po

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