New York Yankees starting pitcher Will Warren (98) in action against the Minnesota Twins at Yankee Stadium in Bronx, New York.

The New York Yankees (66-57) and St. Louis Cardinals (61-63) tangle in the Sunday finale of a 3-game series at Busch Stadium. The interleague contest is ticketed for a 2:15 p.m. ET start time. Let's analyze BetMGM Sportsbook's MLB odds around the Yankees vs. Cardinals odds and make our expert MLB picks and predictions for the best bets.

Season series: New York leads 2-0

A banged-up Yankee lineup still managed 15 hits, as New York clubbed its way to a 12-8 triumph over St. Louis Saturday. With 1B Ben Rice cranking out 3 hits as part of a 7-RBI game, the Yanks beat the Cardinals for a second straight night (4-3 win Friday) and won for the fourth time in their last 5 games.

St. Louis has lost 4 straight games, all at home. The Redbirds, who were 9 games over-.500 on June 30, are 14-25 across their last 39 games.

Yankees at Cardinals projected starters

RHP Will Warren vs. RHP Miles Mikolas

Warren (7-5, 4.34 ERA) is making his 26th start. He has a 1.37 WHIP, 4.0 BB/9 and 10.3 K/9 through 122 1/3 innings.

  • Last outing: Win, 6 2/3 IP, 2 ER, 3 H, 0 BB, 7 K in 6-2 win vs. Minnesota Twins Monday
  • Career vs. Cardinals: 0-1, 9.00 ERA (4 IP, 4 ER), 5 H, 3 BB, 3 K in 1 start in 2024
  • Has registered a 1.93 ERA over his last 4 starts

Mikolas (6-9, 4.97 ERA) is making his 24th start. He has a 1.28 WHIP, 1.9 BB/9 and 6.0 K/9 through 117 2/3 innings.

  • Last outing: No-decision, 6.2 IP, 2 ER, 4 H, 1 BB, 3 K in 3-2 win vs. Colorado Rockies Monday
  • Career vs. Yankees: 1-0, 3.97 ERA (11.1 IP, 5 ER), 11 H, 2 BB, 8 K in 2 starts
  • Has allowed just 4 runs over his last 23 1/3 IP at Busch Stadium

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Yankees at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:38 a.m. ET.

  • Moneyline (ML): Yankees -155 (bet $155 to win $100) | Cardinals +125 (bet $100 to win $125)
  • Run line (RL)/Against the spread (ATS): Yankees -1.5 (+105) | Cardinals +1.5 (-130)
  • Over/Under (O/U): 9 (O: -130 | U: +100)

Yankees at Cardinals picks and predictions

Prediction

Yankees 5, Cardinals 3

Moneyline

The New York offense has registered a dozen round-tripper's in its last 5 games. Warren's 2025 season has been a tale of 2 venues: he has logged a 6.48 ERA on the road and a 2.86 mark at home. But that road number has been alongside a .367 batting average on balls in play, and the sophomore righty has lately been giving the Yankees solid efforts on the mound.

Mikolas has similar home/road splits, and his 3.56 home ERA has been aided by a .247 BABIP. The 36-year-old makes this start on 5 days' rest. That interval has produced an .845 OPS-allowed across 11 previous such starts. And Mikolas does have a history of August/September fades.

Overnight money has come in on the side of a New York team finding a good stride of late. Some of the air is out of the value balloon. Consider a partial-unit play on the YANKEES (-155).

Run line/Against the spread

No interest; PASS.

Over/Under

Hot weather is expected for this one. And the New York bullpen is not in great shape when it comes to availability status in the back end. Still, the Under has held sway in recent games for both sides (6-3-1 in Yankees' last 10 games, 6-4 in Cardinals' last 10), and both starting pitchers Sunday have expected-ERA numbers lower than surface ones.

File a slight lean on the UNDER 9 (+100).

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This article originally appeared on Sportsbook Wire: New York Yankees at St. Louis Cardinals odds, picks and predictions

Reporting by Skip Snow, Sportsbook Wire / Sportsbook Wire

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