The incident happened at 11.07am today (August 15).
Officers arrested three men on suspicion of possession of a bladed article and possession of a class B drug.
They remain in custody.
Homerton High Street was blocked off eastbound during the incident.
Hackney Homerton High Street: Road close after police incident
A spokesperson for the Metropolitan Police said: "At 11:07hrs on Friday, 15 August, officers attempted to stop a vehicle which had made off at speed and collided with a police car on Homerton High Street.
"Officers arrested three men on suspicion of possession of a bladed article and possession of a class B drug.
"They remain in custody."