The Chicago Cubs and the Pittsburgh Pirates battle in the second game of their series on Saturday. The Pirates came away with a 3-2 win over the Cubs on Friday, snapping their five-game losing streak. Chicago has now dropped four of its last five outings. Mike Burrows (1-4, 4.66 ERA) starts for the Pirates. Shota Imanaga (8-5, 3.19 ERA) will take the mound for the Cubs.

First pitch from Wrigley Field is set for 2:20 p.m. ET. Chicago is a -222 favorite (risk $222 to win $100) in the latest Pirates vs. Cubs odds from DraftKings Sportsbook, while Pittsburgh is a +183 underdog (risk $100 to win $183). The over/under for total runs scored is 8.5. Before making any Pirates vs. Cubs picks, be sure to see the MLB betting predictions from SportsLine's proven model.

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