The Pittsburgh Pirates (51-71) and the Chicago Cubs (68-52) begin a three-game series between NL Central rivals on Friday afternoon. Pittsburgh is in a massive slump, as the Pirates have lost six straight games. The Brewers beat the Pirates 12-5 on Wednesday. The Cubs lost 2-1 at the hands of the Toronto Blue Jays yesterday. Colin Rea (9-5, 4.09 ERA) starts for Chicago. Pittsburgh has yet to announce its starter.

First pitch from Wrigley Field is set for 2:20 p.m. ET. The Cubs are the -202 money-line favorites in the latest Pirates vs. Cubs odds from FanDuel Sportsbook, while the over/under for total runs scored is 9. Before making any Pirates vs. Cubs picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model .

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