TOPLINE:

In planned cesarean deliveries, cefazolin demonstrates superior infection prevention compared with clindamycin plus gentamicin, with significantly lower rates of inpatient antibiotic use (5.9% vs 15.2%) and readmissions (1.8% vs 3.8%).

METHODOLOGY:

Researchers conducted a retrospective cohort study at a university-affiliated tertiary medical center between 2012 and 2023, including women undergoing planned cesarean delivery.

Analysis included 11,246 eligible women with 10,588 receiving cefazolin (standard regimen) and 658 receiving clindamycin plus gentamicin (alternative regimen) because of severe penicillin or cephalosporin allergies.

Prophylactic antibiotics were administered within 30 minutes before incision with cefazolin dosing at 2 g (3 g for women weighing ≥ 120 kg) an

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