TOPLINE:

Among UK healthcare workers, seasonal flu vaccination substantially lowered the risk for infection during the winter of 2023-2024, and vaccinated staff recorded fewer positive influenza tests than their unvaccinated peers.

METHODOLOGY:

Researchers in England conducted a prospective cohort study to determine the vaccine effectiveness against influenza infection in 4934 UK healthcare workers (median age, 55 years; 78.7% women; 85.6% White) between September 2023 and March 2024.

Participants submitted respiratory swabs for influenza testing and completed online questionnaires every fortnight; status of seasonal influenza vaccination was confirmed via follow-up questionnaires and linked national registry data.

The primary outcome was polymerase chain reaction (PCR)-positi

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