TOPLINE:

The use of antidepressants during the first trimester was associated with a small but clinically insignificant increase in the risk for miscarriage ; however, no evidence existed to suggest that their use prior to pregnancy and into the first trimester was associated with an increased risk.

METHODOLOGY:

Researchers conducted a population-based cohort study using the UK Clinical Practice Research Datalink GOLD database to evaluate the association between antidepressant use during the first trimester and the risk for miscarriage.

They included 1,021,384 eligible singleton pregnancies with known outcomes between 1996 and 2018; participants were registered at up-to-standard practices and had at least 1 year of follow-up before and through the end of pregnancy.

Researchers ident

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