Looking to begin the season in style, No. 21 Iowa State faces No. 20 Kansas State at 11 a.m. CT Saturday inside Ireland's Aviva Stadium. ESPN will televise the contest.

All eyes will be on this ranked matchup in Week 0, which will quite literally kick off the 2025 college football season. With only four other FBS games scheduled on this first Saturday of football, this Big 12 showdown is easily the most intriguing matchup of the day.

Picks, predictions and odds have been flying in for this early-season showdown. Here's how several experts believe the Iowa State-Kansas State matchup will go. Watch Iowa State vs. Kansas State

Iowa State vs. Kansas State odds, money line, over/under

Odds courtesy of BetMGM Expert MLB daily picks: Unique MLB betting insights only at USA TODAY

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