Multiple people are dead after a tour bus with more than 50 passengers lost control and rolled over on a major highway in upstate New York on Friday, state police said.

The bus was traveling back to New York City from Niagara Falls, police said. It was going eastbound on the New York State Thruway near Pembroke, around 30 miles northeast of Buffalo and 40 miles southeast of Niagara Falls.

"For unknown reasons, the vehicle lost control, went into the median, over-corrected and ended up in the ditch" on the side of the road, state Trooper James O'Callaghan said. The bus was going full speed, but did not hit any other vehicle, he said.

There were "multiple fatalities, multiple entrapments and multiple injuries," O'Callaghan said. At least one child was believed to be among the fatalities,

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