Fans, scrub in— Grey’s Anatomy Season 22 is officially confirmed for its Fall return on October 9, 2025, airing Thursdays at 10 PM ET/PT on ABC and streaming the next day on Hulu . With only two cast members fully confirmed so far, negotiations are underway for several others, and rumors about the show’s possible end, Season 22 promises major changes for Grey Sloan Memorial.

What’s Coming Next

ABC renewed the series in April 2025, continuing its reign as the longest-running medical drama on primetime television. Executive producer Betsy Beers highlights that the show’s strength lies in its mix of new personalities, evolving conflicts, and compelling high-stakes medical plots. The first episode alone promises emotional payoff from Season 21’s hospital explosion cliffhanger.

The

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