TOPLINE:

In a study of BRCA carriers diagnosed with breast cancer during pregnancy, 36.6% successfully had subsequent pregnancies, with no concerning signals seen for maternal prognosis. Patients who conceived were typically younger at diagnosis and more likely to have triple-negative tumours.

METHODOLOGY:

Researchers conducted a retrospective cohort study including 282 BRCA carriers diagnosed with breast cancer during pregnancy (median age at diagnosis, 33 years) between January 2000 and December 2020.

Primary endpoints were the cumulative incidence of a subsequent pregnancy and disease-free survival; secondary endpoints were overall survival, patterns of disease-free survival events, and reproductive outcomes.

Overall, 68 patients had subsequent pregnancies, whereas 214 did no

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