After a four-game FBS appetizer in Week 0, the 2025 college football season kicks into high gear over Labor Day Weekend. There are college football games every day from Thursday to Monday, including some of the most anticipated showdowns of the season. It's an absolutely loaded Week 1 college football odds board that leaves bettors with almost endless opportunities to lock in their college football best bets.

No. 1 Texas is a 2.5-point underdog against No. 3 Ohio State, No. 8 Alabama is -13.5 vs. Florida State and No. 4 Clemson is -3.5 against No. 9 LSU. Those are just a few of the top college football lines to consider. Before locking in any college football picks for Week 1 of the 2025 season, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Mars

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