HOUSTON -- Texans running back Joe Mixon won't be activated from the non-football injury list by Tuesday's 4 p.m. ET deadline, making him ineligible to play at least the first four games this season due to an ankle injury.

Mixon, who injured his ankle over the offseason, will be moved to reserve/non-football injury list before Tuesday's deadline.

Mixon, 29, rushed for 1,016 yards and 11 touchdowns in 2024, earning him Pro Bowl honors in his first season for the Texans.

The Texans took steps to offset Mixon's potential absence this offseason by signing four-time Pro Bowl running back Nick Chubb after his seven-year stint with the Cleveland Browns and drafting Woody Marks out of USC in the fourth round of April's NFL draft.

Mixon missing time during the season always appeared t

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