HOUSTON -- Texans running back Joe Mixon won't be activated from the non-football injury list by Tuesday's 4 p.m. ET deadline, making him ineligible to play at least the first four games this season due to an ankle injury.

Mixon, who has an ankle injury, will be moved to the reserve/non-football injury list before Tuesday's deadline.

Mixon, 29, rushed for 1,016 yards and 11 touchdowns in 2024, earning him Pro Bowl honors in his first season with the Texans.

The team took steps to offset Mixon's potential absence this offseason by signing four-time Pro Bowl running back Nick Chubb after his seven-year stint with the Cleveland Browns and drafting Woody Marks out of USC in the fourth round of April's NFL draft.

Mixon missing time during the season always appeared to be likely wh

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