Week 1 of the 2025 college football season boasts a loaded schedule with top-10 matchups and revenge games, and the spotlight falls squarely on the quarterbacks. Unless everyone runs the table, expect some shakeups in the next AP Top 25 on Tuesday.

Several top programs are breaking in new QBs, from the Arch Manning takeover at Texas to Julian Sayin filling the shoes of national championship-winner Will Howard at Ohio State. Just like Manning-Sayin, Heisman Trophy hopefuls Garrett Nussmeier and Cade Klubnik will also go head-to-head, while Notre Dame and Miami debut new starters with a vast difference in experience.

The theme is common across six can’t-miss Week 1 games: How the QBs perform could set the tone for the playoff hunt as early as this weekend:

No. 1 Texas at No. 3 Ohio State

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