The ACC Tigers host the SEC Tigers as No. 4 Clemson faces No. 9 LSU in a must-see Week 1 battle on Saturday night. Clemson finished its 2024 season 10-4 overall and 7-1 in conference play before defeating SMU to win the conference. They host an LSU side that finished 9-4 and has a long list of players returning this season.

Kickoff from Memorial Stadium in Clemson is set for 7:30 p.m. ET. Clemson is a 4-point favorite in the latest LSU vs. Clemson odds from SportsLine consensus, while the over/under for total points scored is set at 57.5. Before making any Clemson vs. LSU picks, make sure you check out the picks from the SportsLine projection model. New users at bet365 can get $200 in bonus bets instantly with the latest bet365 bonus code for Saturday's game:

The model sim

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