A big-time showdown to start the 2025 college football season has the No. 9 LSU Tigers on the road to play against the No. 4 Clemson Tigers. Last season, Clemson finished with a 10-4 record and got eliminated in the first round of the College Football Playoff by Texas, 38-24. On the opposite sideline, LSU logged a 9-4 record last year and took down Baylor, 44-31, in the Kinder's Texas Bowl.

Kickoff from Memorial Stadium in Clemson is set for 7:30 p.m. ET. Clemson is a 4-point favorite in the latest LSU vs. Clemson odds from SportsLine consensus, while the over/under for total points scored is set at 57.5. Before making any Clemson vs. LSU picks or same-game parlays, be sure to see the Week 1 college football predictions from SportsLine's proven model and check out the latest college fo

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