The 2025 NFL regular season kicks off on Thursday, September 4, with the defending Super Bowl champion Philadelphia Eagles hosting the Dallas Cowboys in the 2025 NFL Kickoff Game. At DraftKings Sportsbook, the Eagles are listed at +700 to repeat as champions, trailing the Buffalo Bills and Baltimore Ravens , who play each other in Week 1 and share the top spot at +600. Week 1 spans Thursday through Monday, highlighted by a Friday international matchup in São Paulo between the Kansas City Chiefs and Los Angeles Chargers , and a Sunday Night Football showdown featuring the Baltimore Ravens against the Buffalo Bills. The opening weekend also features heavyweight matchups like the Lions vs. Packers and 49ers vs. Seahawks .

Who should you back in each of the 16 games on the Week

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