The NFL opener regularly turns into one of the most heavily bet regular-season games of the entire year, and Thursday's matchup between the Dallas Cowboys and Philadelphia Eagles is no exception.

By the time the last bet is placed on Thursday's opener, gambling experts estimate that hundreds of millions of dollars will be on the line across the nation just with U.S. sportsbooks, not including how much is in play at daily fantasy sites, prediction markets, offshore sportsbooks and with local bookmakers.

"The excitement of football returning really reignites bettors," said Joey Feazel, who oversees football odds for Caesars Sportsbook, adding that the company nearly tripled the betting options for football in preparation for the NFL season. "Eagles-Cowboys is lining up to be the bigges

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