Delaware Blue Hens quarterback Nick Minicucci in action against the Delaware State Hornets at Delaware Stadium in Newark, Delaware.

The Delaware Blue Hens (1-0) visit the Colorado Buffaloes (0-1) in a Saturday clash in Boulder. The contest at Folsom Field will kick off at 3:30 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NCAA football odds around the Delaware vs. Colorado odds and make our expert college football picks and predictions for the best bets.

Delaware is in its inaugural season as an FBS program and is facing Colorado for the first time. The Blue Hens opened their season Aug. 28 with a 35-17 triumph over the FCS Delaware State Hornets. QB Nick Minicucci went 28-for-36 (77.8%), throwing for 275 yards with 3 TDs and no picks. For good measure, the UD signal caller added 44 rushing yards and a score on the ground.

The Buffaloes opened with a Week 1 home loss against the Georgia Tech Yellow Jackets. Colorado failed to leverage a plus-3 in turnovers and was outgained 463-305 yards in a 27-20 loss. The Buffs allowed 6.8 rushing yards per carry.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Delaware at Colorado odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 3:47 p.m. ET.

  • Moneyline (ML): Delaware +1100 (bet $100 to win $1100) | Colorado -2500 (bet $2500 to win $100)
  • Against the spread (ATS): Delaware +23.5 (-110) | Colorado -23.5 (-110)
  • Over/Under (O/U): 49.5 (O: -115 | U: -105)

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Delaware at Colorado picks and predictions

Prediction

Colorado 35, Delaware 20

Moneyline

No interest. PASS.

Against the spread

Colorado has failed to cover the spread in 6 of its last 7 games against non-conference opponents at Folsom Field. The Buffaloes are 0-6 ATS in their last 6 games lined as a favorite of 20 points or more.

Even with Shedeur Sanders and Travis Hunter on the field, CU struggled mightily in their 2024 season lid-lifter at home against FCS North Dakota State. These 2025 Buffaloes have lost a lot of production, especially on offense, and Saturday's game could well be in doubt late well into the second half.

Yes, Delaware will be dealing with plenty of jump-in-class issues this fall. But UD won 9 games each of the last 2 seasons. Look for the Blue Hens to be able to play enough representative ball across the first 2-3 quarters here. And having a QB that can scramble under duress will only help.

DELAWARE +23.5 (-110) is the value side of this game.

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Over/Under

The Over is 6-3-1 in CU's last 10 home games.

Good weather is expected for this afternoon game in Boulder. The Colorado defense has some questions, and both sides have enough facets to what they do well on offense to push this final tally close to 60. Some turnover-driven, short-field action also figures to play into this one.

TAKE THE OVER 49.5 (-115).

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This article originally appeared on Sportsbook Wire: Delaware Blue Hens at Colorado Buffaloes odds, picks and predictions

Reporting by Skip Snow, Sportsbook Wire / Sportsbook Wire

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