The James Madison Dukes battle the Louisville Cardinals in a Week 2 college football matchup on Friday. James Madison is coming off a 45-10 win over Weber State, while Louisville opened its season with a 51-17 win over Eastern Kentucky. The Dukes, who were 9-4 overall last season, were 3-3 on the road a year ago. The Cardinals, who were also 9-4, are 5-2 on their home field since the start of 2024.

Kickoff is set for 7 p.m. ET at L&N Federal Credit Union Stadium in Louisville, Ky. Louisville won the only meeting with James Madison, 34-10 in 2022. The Cardinals are 15.5-point favorites in the latest James Madison vs. Louisville odds, while the over/under for total points scored is 55. Before making any Louisville vs. James Madison picks, be sure to see what SportsLine expert Mike Tie

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